文章編號：1000-8020（2006）06-0747-03

摘要：目的  找出嚴重乳糖不耐受者最低可接受牛奶攝入量，再觀(guān)察此量在健康成人中的耐受情況。方法  采用氫呼氣試驗從38名受試者中篩選出8名有水樣狀腹瀉的乳糖不耐受者，分成低、高劑量組參加飲奶試驗。兩組癥狀評分之和大致相等，據文獻報道及單因素優(yōu)選法（黃金分割法）確定兩組對象分別飲用25g和38.2g奶粉（分別含6.25g和9.55g乳糖）和水沖調成的200ml牛奶，分析受試者氫呼氣濃度變化值、癥狀評分、糞便乳糖含量（醋酸鉛法）。采用隨機整群抽樣方法選取健康的100名青年、80名中年、100名老年人，觀(guān)察攝入25g奶粉后出現的耐受癥狀。結果  兩組受試者在飲奶試驗中無(wú)一例腹瀉發(fā)生，僅有不同程度的輕微癥狀；高劑量組（B組）對象飲奶后，其氫呼氣濃度、癥狀評分、糞便乳糖均高于低劑量組（A組）。健康成人飲用25g奶粉沖調的牛奶后, 80.3%的對象未產(chǎn)生任何乳糖不耐受癥狀。結論  本研究結果表明健康成人即使為乳糖不耐受者也能飲用適量牛奶，大多數健康成人攝入25g奶粉（含乳糖6.25g）后不會(huì )出現任何乳糖不耐受癥狀，建議20g奶粉（含乳糖5g，配成160 ml 牛奶）作為我國成年人的最低可接受牛奶攝入量。

關(guān)鍵詞：乳糖不耐受  可接受牛奶攝入量  單因素優(yōu)選法  糞便乳糖  氫呼氣試驗（HBT）

 

Department of Nutrition and Food Hygiene, Huaxi School of Public Health,Sichuan University,Chengdu  610041, China

 

Abstract：Objective  To find out the lowest acceptable intake of cow’s milk in subjects with lactose intolerance(LI)and then observe intolerance symptoms in 280 healthy adults after they drank the milk.  Methods  Eight LI subjects with watery diarrhea who were selected from 38 subjects by hydrogen breath test(HBT) were divided into group A, group B to go on drinking cow’s milk test． The subjects in group A ingested 25g milk powder, the subjects in group B ingested 38.2g milk powder(contain 6.25g, 9.55g lactose respectively) according to literature and single factor optimization method（0.618 golden mean） to analyze their hydrogen excretion(ppm) ,symptom score and stool lactose． The 100 younger， the 80 middle-age and the 100 elder subjects were selected to observe symptoms after they  ingested 25g milk powder.  Results   hydrogen excretion(ppm) and symptom score in the high dose group (group B)are a little higher than those in low dose group（group A）.  No case with diarrhea occurred in these two group but mild symptoms. Most of healthy adults(80.3%) have no intolerance symptoms after they drank the milk. Conclusion   The study demonstrates that most of adults, even with LI, can tolerance 25g cow’s milk powder(6.25g lactose) .  It is suggested 20g cow’s milk powder(5g lactose，make 160ml of milk solution) is the lowest acceptable intake of healthy adults in China.

Key words: lactose intolerance，acceptable intake of cow’s milk，single factorial optimization method stool lactose，hydrogen breath test(HBT)

 

 

基金項目：國家自然科學(xué)基金資助項目（No.30271126）

作者簡(jiǎn)介：?jiǎn)倘兀┦垦芯可F工作單位：四川大學(xué)華西第二醫院營(yíng)養室

1通訊作者

2Groningen University, Netherland

文章編號：1000-8020（2006）06-0754-02

 

李增寧  楊惠霞¹  張祥宏²  康維鈞³ 談敦芳³  崔晉峰 王俊靈 申海濤 汲建軍⁴ 米建民⁵

河北醫科大學(xué)基礎所實(shí)驗病理室，石家莊   050017

摘要：目的 探討河北省食管癌、胃癌高發(fā)區居民食用小麥赭曲霉素A污染情況，了解居民的可能暴露量。方法 深入高發(fā)區現場(chǎng)隨機選取當地居民正在食用的小麥樣品，利用反相—液相色譜法測定其赭曲霉素A含量。結果 河北省胃癌高發(fā)區贊皇縣居民食用小麥樣品中赭曲霉素A的檢出率為45.16%，平均含量2.41μg/kg，最高達14.25μg/kg。河北省磁縣食管癌高發(fā)區居民食用小麥中赭曲霉素A的檢出率為33.33%，平均含量0.59μg/kg，最高為1.63μg/kg。結論 河北省胃癌食管癌高發(fā)區居民食用小麥赭曲霉素A的檢出率明顯高于國內其它地區的有關(guān)文獻報道，應引起腫瘤防治工作者的重視。

關(guān)鍵詞：食管癌  胃癌  赭曲霉毒素A  液相色譜

 

 

 

作者簡(jiǎn)介：李增寧，男，博士研究生

1石家莊市第三醫院

2通訊作者：zhangxh@hebmu.edu.cn

3河北醫科大學(xué)公共衛生學(xué)院

4邯鄲市衛生局

5贊皇縣醫院

 

文章編號：1000-8020（2006）06-0756-03

翟鳳英 胡以松 姚崇華[1] 王文志² 樸建華 楊曉光

中國疾病預防控制中心營(yíng)養與食品安全所，北京 100050

 

摘要：目的  探討中國居民代謝綜合征與腦卒中的關(guān)系。方法  數據來(lái)源于2002年中國居民營(yíng)養與健康狀況調查，選擇15歲以上人群48633例，其中男性23080例，女性25553例。代謝綜合征的定義參考中國醫學(xué)會(huì )糖尿病分會(huì )2004年建議的標準。結果  單因素logistic回歸分析表明，代謝綜合征與腦卒中呈正相關(guān)，OR值為5.998(95%CI 4.799~7.496)，多因素分析調整年齡、性別、6類(lèi)地區、教育程度、中重度體力活動(dòng)時(shí)間、吸煙、飲酒后代謝綜合征與腦卒中仍具有統計學(xué)相關(guān)性，OR值為3.114(95%CI 2.432~3.987)。代謝綜合征的所有組分中，高血壓與腦卒中的相關(guān)性最強，且隨著(zhù)代謝綜合征組分在個(gè)體聚集越多（趨勢性檢驗P<0.0001），患腦卒中的可能性越大。結論  中國居民代謝綜合征與腦卒中的患病有關(guān)。

關(guān)鍵詞：腦卒中  代謝綜合征

 

Institute of Nutrition and Food Safety, Chinese Center for Disease Prevention and Control,Beijing 100050, China

Abstract：Objective  To explore the relationship between metabolic syndrome and stroke in Chinese people  Methods  Data were presented for 23080 men and 25553 women aged more than 15 years old from National Nutrition and Health Survey, 2002. Metabolic syndrome definition was recommended by the CDS .  Results  The metabolic syndrome was significantly related with stroke(OR=5.998, 95%CI 4.799-7.496) in univariate logistic analysis, after being adjusted for age, sex, area, education, physical activity smoking and drinking, the relationship still exists between the metabolic syndrome and stroke(OR=3.114, 95%CI 2.432-3.987) . Among the component conditions, hypertension was the most leading factor associated with stroke. And individual with more components has more possibility to be affiliated with stroke(P trend less than 0.0001). Conclusion  The metabolic syndrome was significantly associated with stroke in Chinese people, the metabolic syndrome and its’ components should be prevented to avoid the prevalence of stroke in Chinese.

 

 

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