文章編號：1000-8020（2006）02-0182-03

李劍虹 樸建華 郭寧 楊麗琛¹ 董杰 楊曉光

中國疾病預防與控制中心營(yíng)養與食品安全所，北京 100050

摘要：目的  了解我國兒童維生素A（VA）的營(yíng)養狀況、VA缺乏率、VA邊緣缺乏率，研究血漿VA與鐵營(yíng)養狀況的相關(guān)性。 方法  由2002年“中國居民營(yíng)養與健康狀況調查”的大樣本中隨機抽取380名3~12歲兒童，檢測血漿VA含量，同時(shí)測定血紅蛋白（Hb）、總鐵結合力（TIBC）、鐵蛋白（SF）及轉鐵蛋白受體（sTfR）。了解兒童VA營(yíng)養狀況，計算VA缺乏率、VA邊緣缺乏率，研究VA與鐵營(yíng)養狀況評價(jià)指標的相關(guān)性。結果  受試兒童VA平均含量為（1.03±0.24）μmol/L，其中8.4%患VA缺乏，44.7%兒童VA邊緣缺乏。血漿VA與Hb呈正相關(guān)（r=0.16986，P<0.01），與sTfR呈負相關(guān)（r=-0.12863，P<0.05），與TIBC、SF不相關(guān)。結論  鐵缺乏伴隨VA邊緣缺乏在我國兒童中普遍存在，VA與鐵營(yíng)養狀況存在相關(guān)性。

關(guān)鍵詞：維生素A   鐵營(yíng)養狀況  相關(guān)性

中圖分類(lèi)號：R153.2   Q562   Q581              文獻標示碼：A

 

 

Li Jian-hong, Piao Jian-hua, Guo Ning, Yang Li-chen, et al

Institute for Nutrition and Food Safety, Chinese CDC, Beijing 10050, China

Abstract: Objects To study vitamin A status, the prevalence of VA deficiency and marginal VA deficiency and the correlation of VA and iron status of Chinese children. Methods 380 children were randomly chosen from “Survey on the Status of Nutrition and Health of the Chinese People” (CNHS) in 2002. The plasma vitamin A, hemoglobin(Hb), total iron-binding capacity(TIBC), ferritin(SF) and soluble transferrin receptor(sTfR) were detected. The prevalence of VA deficiency and marginal deficiency was assessed and the correlation of VA and iron indexes was studied. Results The VA concentration of subjects was （1.03±0.24）μmol/L. The prevalence of VA deficiency and VA marginal deficient was 8.4%, 44.7% respectively. Plasma VA was positively correlated with Hb（r=0.16986，P<0.01） and negatively correlated with sTfR（r=-0.12863，P<0.05） significantly but there was no association of SF and TIBC. Conclusion Iron deficiency coexisted VA marginal deficiency are still very prevalent in Chinese children, plasma VA are correlated with iron status.

Key words: vitamin A, iron status, correlation

 

 

基金項目：國家自然科學(xué)基金面上項目（No. 30400351）

作者簡(jiǎn)介：李劍虹，女，博士研究生

1通訊作者

薛琨   郭紅衛¹   陳鳳麟

復旦大學(xué)公共衛生學(xué)院營(yíng)養與食品衛生教研室，上海  200032

 

摘要：目的  研究中鏈脂肪酸（MCFA）對營(yíng)養性肥胖大鼠體重、體脂、血脂水平的影響。方法  采用預防肥胖模型法，每天給予SD大鼠高脂營(yíng)養飼料，并灌胃含不同劑量MCFA的食用油脂，飼養38天，觀(guān)察體重、攝食量、體脂重量、血脂、胰島素水平在不同劑量組動(dòng)物間的差異。結果  高、中、低三個(gè)劑量組大鼠分別攝入0.975、0.325、0.163g/kg bw MCFA38天，高劑量組與模型對照組相比，體重明顯較低[分別(295.2±29.7)g和(324.6±9.1)g]（P<0.05），脂肪墊重量明顯較輕[分別（5.30±1.57）g和（7.20±1.74）g]（P<0.05），脂肪細胞明顯較小；各劑量組總的攝食量不顯著(zhù)低于模型對照組；血清甘油三酯（TG）、總膽固醇（TC）、胰島素水平與模型對照組比較差異無(wú)顯著(zhù)性，中、高劑量組高密度脂蛋白膽固醇（HDL-C）水平高于模型對照組[分別（0.71±0.11）mmol/L、（0.73±0.12）mmol/L、（0.60±0.06）mmol/L]，P<0.05），高劑量組大鼠的瘦素水平顯著(zhù)低于模型對照組[分別（1.61±0.39）ng/ml和（2.04±0.46）ng/ml]（P<0.05）。結論 在飼料攝入量沒(méi)有差別的前提下，攝入0.975g/kg bw MCFA對營(yíng)養性肥胖大鼠的體重增長(cháng)有一定抑制作用，對血脂水平?jīng)]有不良影響。

關(guān)鍵詞：中鏈脂肪酸  營(yíng)養性肥胖大鼠  肥胖預防  血脂 脂肪細胞

 

Xue Kun, Guo Hong-wei, Chen Feng-lin

Public Health School of Fudan University, Shanghai  200032, China

 

Abstract: Objective  Some researchers considered medium chain fatty acids a group of potential agents in the prevention of obesity for their particular metabolism characters. Methods  In this study we investigated the effects of medium chain fatty acids on body weight gains, food intake, adipose depots and serum lipid profiles. Healthy male Sprague-Dawley rats were fed for 38 days with over-fat diets and oils containing MCFA at different level. Results  Significant decreases of body weight[(295.2±29.7)g vs. (324.6±9.1)g](P<0.05), the weight of adipose pads [(5.30±1.57)g vs (7.20±1.74)g](P<0.05), the level of Leptin in serum[(1.61±0.39)ng/ml vs (2.04±0.46)ng/ml] (P<0.05）, the sizes of fat cells but increase of HDL-C [(0.73±0.12)mmol/L vs （0.60±0.06）mmol/L](P<0.05 )  were noted in the group fed MCFA at 0.975g/kg bw per day as compared with those of the group fed soybean oil. Conclusion  The results suggested the role of MCFA in prevention of obesity and there is no adverse effect on lipid metabolism if the proportion of MCFA to total fat scouce is mild.

Key words：medium-chain fatty acids，food-induced obesity rats，obesity prevention，blood lipid，adipocyte

 

作者簡(jiǎn)介：薛琨，女，碩士

1通訊作者：郭紅衛  教授
文章編號：1000-8020（2006）02-0191-03

 

宋琳亮 羅云波  石階平

中國農業(yè)大學(xué)食品科學(xué)與營(yíng)養工程學(xué)院，北京 100083

 

摘要：目的  研究不同共軛亞油酸對人類(lèi)胃癌細胞AGS、肝癌細胞Bel7402和腸癌細胞Lovo細胞增殖的影響。方法  采用體外培養的AGS、Bel7402和Lovo細胞為模型，測定不同處理后活細胞數量。結果  研究采用的五種共軛亞油酸異構體都對AGS、Bel7402和Lovo細胞增殖表現出了抑制作用，對AGS的抑制作用要普遍高于對Bel7402和Lovo的抑制作用，并且濃度不同，抑制作用也具有差異。結論  五種共軛亞油酸異構體都具有抑制癌細胞增殖的作用，并且這種作用受到共軛亞油酸濃度的影響。

關(guān)鍵詞：共軛亞油酸  細胞增殖  AGS  Bel7402  Lovo

 

Song Lin-liang, Luo Yun-bo, Shi Jie-ping

College of Food Science & Nutritional Technology, China Agricultural University, Beijing 100083, China

 

Abstract：Objective  To study the effect of five conjugated linoleic acid isomers on the proliferation of human tumor cell AGS and Bel7402. Methods  AGS, Bel7402 and Lovo cells incubated in vitro were used as model. The cell visibility was investigated after treatment with CLA. Results  All the five isomers had inhibitory ability to AGS, Bel7402 and Lovo cell proliferation, and the effect on AGS was more effective than that on Bel7402 and Lovo. The inhibitory effect was dose-dependent. Conclusion  The five isomers of CLA exhibited proliferation inhibitory effect on the tumor cell of AGS and Bel7402.

Key words：conjugated linoleic acid, proliferation, AGS, Bel7402, Lovo

 

 

作者簡(jiǎn)介：宋琳亮，女，博士

1通訊作者